There's countless mashups that use Van Halen's "Jump", but The Kleptones "Jump On You F**ker" - which mashes up the Van Halen brothers, David Lee Roth and the underrated Michael Anthony on bass with Cee-Lo's "F**k You" - is the most recent and most awesome.
FUN FACT: When I was a teenager I wanted to be Eddie Van Halen. Even tried to tape up my guitar to look exactly like his.
FUN FACT PART 2 THAT I ONLY FOUND OUT WHILE GOOGLING IMAGES OF EDDIE VAN HALEN'S GUITAR: He sued Nike! Wow. That's like me finding out that Charmane Star sued Tera Patrick.